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    Silvia FASANO

    Insegnamento di APPLIED BIOLOGY

    Corso di laurea magistrale a ciclo unico in MEDICINA E CHIRURGIA

    SSD: BIO/13

    CFU: 9,00

    ORE PER UNITÀ DIDATTICA: 90,00

    Periodo di Erogazione: Primo Semestre

    English

    Teaching language

    English

    Contents

    At the end of the course students should know:
    -the organization of living matter, the cell both from the point of view morphological and functional
    -the flow of information from DNA to proteins
    -the reproduction
    -mechanisms which are at the basis of phenomena of inheritance

    Textbook and course materials

    Karp G - Cell and molecular biology - John Wiley & Sons, Inc
    Snustad DP- Principles of genetics - John Wiley & Sons, Inc

    Course objectives

    Definition of life,The Discovery of Cells, Basic Properties of Cells, Prokaryotes and Eukaryotes, Eukaryote cell, Viruses. Species concept, the principle of classification.
    The molecular organization of life
    Water, Carbohydrates, Lipids, ProteinsThe Structure and Function of the Plasma Membrane
    A Brief History of Studies on Plasma Membrane Structure
    The Chemical Composition of Membranes, The Structure and Functions of Membrane Proteins, Membrane Lipids and Membrane Fluidity, The Dynamic Nature of the Plasma Membrane, The Movement of Substances Across Cell Membranes.
    Cell Signalling and Signal Transduction: Cell Communication
    The Basic Elements of Cell Signalling Systems, A Survey of Extracellular Messengers and Their Receptors, Protein-Tyrosine Phosphorylation as a Mechanism for Signal Transduction, G Protein-Coupled Receptors and Their Second Messengers, The Role of Calcium as Intracellular Messenger, Convergence, Divergence, and Cross-Talk Among Different Signalling Pathways. Apoptosis
    Nuclear compartment
    Cytoplasmic Membrane Systems, Membrane Trafficking: Intracellular Compartments and Protein Sorting
    The Endoplasmic Reticulum, The Golgi Complex, Types of Vesicle Transport and Their Functions, Lysosomes.
    Mitochondria
    The cytoskeleton
    Cellular Reproduction
    The Cell Cycle control, M Phase: Mitosis and Cytokinesis. The Discovery and
    Characterization of MPF, Basic Properties of a Cancer Cell. Sexual Reproduction.
    Germ Cells, Meiosis, Meiotic Nondisjunction and Its Consequences, Gametogenesis
    Fertilization

    Prerequisites

    General Chemestry

    Teaching methods

    OralLessons

    Evaluation methods

    Oral Examination and In Itinere Tests

    Other information

    Lecture, Tutorial in small groups

    Course Syllabus

    SYLLABUS 2018/2019

    CORSO INTEGRATO BIOLOGY, MOLECULAR BIOLOGY, GENETICS
    COORDINATORE
    DOCENTI Proff. Silvia Fasano, Umberto Galderisi, Sergio Minucci
    OBIETTIVI DEL CORSO


    at the end of the course students should know:
    -the organization of living matter, the cell from both morphological and functional point of view
    -the flow of information from DNA to proteins
    -the reproduction
    -basic mechanisms of inheritance
    PROGRAMMA D'ESAME
















    The molecular organization of life
    Water, Carbohydrates, Lipids, Proteins
    -Molecular Biology and Medicine: course introduction
    - Experiments of Avery, Griffith, Hershey and Chase
    -Nucleic acids structure: DNA, RNA
    -Nucleic acids functions: DNA, RNA
    -RNA: ribosomal, transfer, mRNAs, small RNAs
    -DNA replication: Meselson and Sthal
    -DNA replication in prokaryotes
    -DNA replication in eukaryotes
    -DNA repair mechanisms
    -RNA polymerase in prokaryotes
    -RNA polymerase in eukaryotes
    -Transcription in prokaryotes and eukaryotes
    -mRNA processing : capping, splicing, polyadenylation
    - Protein synthesis
    - Genetic code
    - Gene expression regulatory mechanisms
    -biological basis of life -
    Prokaryotes and Eukaryotes
    Eukaryote cell
    Plasma membrane
    Nuclear compartment
    Cytoplasmic organelles
    The cytoskeleton
    -Protein sorting
    Cell-to cell communications
    Virus
    Cell cycle
    -Reproduction
    Genetics
    -Mendel: The Basic Principles of Inheritance
    -Extension of mendelism
    -Linkage (Batesons and Punnet- Morgan experiments)
    -X-linked traits (Morgan experiments)
    -Genes and environment
    -Sex chromosomes and sex determination
    -Pedigree
    -Mitocondrial inheritance/maternal effect
    -Gene, chromosomal and genomic mutations
    LIBRI DI TESTO
    CONSIGLIATI Karp G - Cell and molecular biology - John Wiley & Sons, Inc
    Snustad DP- Principles of genetics - John Wiley & Sons, Inc
    ORARIO RICEVIMENTO For any problem, please use the following contacts:
    Prof.Fasano 0815665837 - Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.
    Prof.Minucci 0815665829 – Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.
    Prof.Umberto Galderisi 0815667585- Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.

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